The Genetics of Rosacea

The Genetics of Rosacea

A new study by researchers from Stanford Medical School and 23andMe is the first to identify genetic variants associated with rosacea, a chronic skin disease estimated to affect more than 16 million people in the United States alone.The Genetics of Rosacea

Led by Dr. Anne Lynn S. Chang, of Stanford University’s School of Medicine, the study to be published in the Journal of Investigative Dermatology, is the first to identify genetic factors for this common but incurable condition. (The link is to a pre-print version of the paper.) Although the genetic basis for rosacea has long been hypothesized, this is the first study to find genetic variants associated with the condition.

The genes identified in the study support the concept of a genetic basis for rosacea and that could in turn help identify new targets for future studies to better understand and treat this condition.

The discovery portion of the study, which involved the consented participation of more than 22,000 23andMe customers, found two genetic variants strongly associated with the disease among people of European ancestry. Of the 22, 000 customers in this part of the study, more than 2,600 of them had rosacea and the other 20,000 did not have the condition and were used as controls.

Although rosacea is not life threatening, it is a serious and still little understood condition. Some of the symptoms include redness, inflammation, visible blood vessels, pimple like sores on the skin of the central face, as well as burning and itching. Left untreated it can lead to more serious complications, including disfiguring of the nose — called rhinophyma — and damage to the cornea causing vision problems. Because the condition is so visible it can make those who have it feel isolated.

“This is also another example of how 23andMe can help in researching common yet understudied diseases,” said
Joyce Tung, PhD, 23andMe’s Director of Research and a co-author of the paper.

Another intriguing finding from this study is that the single nucleotide polymorphisms (SNPs) found to be strongly associated with the condition, are in or near genes associated with other diseases including diabetes and celiac disease. One of the SNPs found strongly associated with the condition, rs763035, is between the genes HLA-DRA and BTNL2. The HLA-DRA gene is involved in histocompatibility and immune response, which is consistent with the inflammatory nature of rosacea.

To validate the association, 23andMe researchers tested the SNPs from the genome-wide association study in a separate group of 29,000 consented 23andMe customers. The researchers were able to confirm the same association with rosacea. For that portion of the study, researchers looked at more than 3,000 individuals with rosacea and 26,000 controls.

In addition to the genome wide association study that discovered the variants associated with rosacea, Dr. Chang and her team also took skin biopsies from six individuals with rosacea and showed that both HLA-DRA and BTNL2 proteins can be found in the skin of people with rosacea. This preliminary works hints toward the biological relevance of HLA-DRA and BTNL2 in rosacea.

The genetic associations found in this study and the associations with other diseases like diabetes and celiac disease may help direct future study.

What People Say Works Best for Acne

What People Say Works Best for Acne

What People Say Works Best for Acne

Some of the most effective treatments for acne are not necessarily drugs, according to a new study by CureTogether, a free resource owned by 23andMe that allows people to share information about their health and treatments.

People in the study said they found that lifestyle changes like a paleo diet, reducing sugar, and getting plenty of sunshine were among the most effective in treating acne. In addition, those who participated in the study said that more conventional medical treatments such as Accutane, which ranked at the top of the list, helped a great deal. Conversely some common treatments such as Clearasil, hydrogen peroxide, and soap, were among the least effective, according to the study.

Acne affects millions of Americans and can be embarrassing to experience. Finding accurate recommendations on treatments that work well can be challenging, so CureTogether asked people suffering from acne to rate the effectiveness of different treatments. The study compiled responses from 4,375 people with acne, who rated the effectiveness of 72 different treatments.

Most Effective Rated Treatments for People with Acne
1. Accutane
2. Paleo diet
3. No gluten
4. Bactrim
5. Sunshine
6. 10% Benzoyl Peroxide cream
7. No sugar
8. Avoid touching face
9. No dairy
10. Birth control pill

Where did this data come from? This is the result of a four-year CureTogether study on Acne, in which people living with the condition shared information about their symptoms and what treatments worked best for them. We’d like to thank those who participated. And just as they shared their experience with treatments, we’re freely and openly sharing the results of the acne study.

This is part of a regular series of CureTogether research findings. CureTogether’s research findings are different than those made by 23andMe, which look at genetic associations with illness, traits and drug response. But as we continue our work with the CureTogether community, 23andMe hopes to incorporate more of this kind of self-reported information into our own research. CureTogether present its findings just as they are — patient-reported data — to stimulate discussion and generate new insights for further research.

Please tweet, blog, or pass this along to anyone who can benefit or is interested in acne. Thank you!

What People Say Works for Eczema

What People Say Works for Eczema

What People Say Works for Eczema

People living with Eczema have reported that some of the most effective treatments for their skin include medications like Clobetisol, Trimacinolone, Elocon, and Fluocinonide. This is according to a new study by CureTogether, a free resource owned by 23andMe that allows people to share information about their health and treatments.

Participants in the study also said they found that simple interventions like avoiding allergens, avoiding sweating or temperature changes, moisturizing often, and reducing stress were also effective. They also said dietary changes help. Conversely some common treatments such as antihistamines, coconut oil, and not washing hair every day were among the least effective, according to the study.

Effective Treatments for Eczema As Rated By Patients
1. Clobetisol
2. Triamcinolone
3. Steroid injection
4. Elocon
5. Fluocinonide
6. Avoid problem foods
7. Avoid allergens
8. Corticosteroid cream
9. Moisturize frequently
10. Reduce stress

According to the National Institutes of Health, Eczema affects 15 million Americans and 10% of young adults worldwide. It can be embarrassing to experience cosmetically, but also impacts people’s quality of life. Finding accurate recommendations on treatments that work well can be challenging, so CureTogether asked people living with Eczema to rate the effectiveness of 32 different patient-reported treatments.

Where did this data come from? This is the result of a four-year CureTogether study on Eczema, in which 1,109 people living with the condition shared information about their symptoms and what treatments worked best for them. We’d like to thank those who participated. And just as they shared their experience with treatments, we’re freely and openly sharing the results of the Eczema study.

This is part of a regular series of CureTogether research findings. CureTogether’s research findings are different than those made by 23andMe, which look at genetic associations with illness, traits and drug response. But as we continue our work with the CureTogether community, 23andMe hopes to incorporate more of this kind of self-reported information into our own research. CureTogether present its findings just as they are — patient-reported data — to stimulate discussion and generate new insights for further research.

Please tweet, blog, or pass this along to anyone who can benefit or is interested in Eczema. Thank you!

 

Causes and Triggers of Eczema

Causes and Triggers of Eczema

The exact causes of eczema are unknown. You might have inherited a tendency for eczema. You may have a family member who has eczema or who has hay fever (allergic rhinitis) or asthma. Many doctors think eczema causes are linked to allergic disease, such as hay fever or asthma. Doctors call this the atopic triad. Many children with eczema (up to 80%) will develop hay fever and/or asthma.

There are many triggers of eczema that can make it flare or get worse. Below are some of the common triggers. You should learn what triggers your eczema to flare, and then try to avoid it.

IRRITANTS:

Causes and Triggers of EczemaIrritants can make your symptoms worse. What irritates you may be different from what irritates someone else with the condition, but could include:

  • Soaps and detergents,
  • Shampoos, dish-washing liquids
  • Bubble Bath
  • Disinfectants like chlorine
  • Contact with juices from fresh fruits, meats, vegetables

 

ALLERGENS:

Causes and Triggers of EczemaIf your genes make you more likely to develop atopic eczema, the condition will develop after you are exposed to certain environmental factors, such as allergens.

Allergens are substances that can cause the body to react abnormally. This is known as an allergic reaction. Some of the most common allergens that can be causes of eczema include:

  • House dust mites
  • Pets (cats > dogs)
  • Pollens (seasonal)
  • Molds
  • Dandruff

 

 MICROBES:

Some types of microbe can be triggers of eczema:

  • Certain bacteria like Staphylococcusaureus
  • Viruses
  • Certain Fungi

 

HOT OR COLD TEMPERATURES:

  • Hot weather
  • High and low humidity
  • Perspiration from exercise

 

FOODS:

Causes and Triggers of EczemaAtopic eczema can sometimes be caused by food allergens, especially before the age of one. Some studies of children and young people with atopic eczema found that one-third to nearly two-thirds also had a food allergy. Food allergies associated with eczema causes are typically:

  • Dairy products
  • Eggs
  • Nuts and seeds
  • Soy products
  • Wheat

 

STRESS:

Stress is known to be associated with eczema but it is not fully understood how it affects the condition. Some people with eczema have worse symptoms when they are stressed. For others their eczema symptoms cause them to feel stressed.

HORMONES:

Hormones are chemicals produced by the body. They can cause a wide variety of effects. When the levels of certain hormones in the body increase or decrease some women can experience flare ups of their eczema.

Benefits of Kigelia Africana Creme

Benefits of Kigelia Africana Creme

Discriminating in the course of sub-Saharan Cameras, trees on the kigelia africana as well as kigelia pinnata variety produce a sizable sausage-size fruits the region’s ancient people possess prolonged useful for therapeutic as well as beauty apps. Several beauty businesses possess known your fruit’s skin-enhancing components through the add-on associated with fruits extract to some in their items. Medical investigation has also found data that kigelia fruits extract may be efficient in helping to help remedy most cancers, your deadliest form of skin color cancers.

kigelia africana creme

Kigelia Africana Creme Antibacterial Effects

Using up on scientific studies that revealed your stalk bark on the kigelia africana owned or operated potent antibacterial components, a group associated with Southern African-american research workers performed a work to see in the event the kigelia fruits offered those positive aspects at the same time. These people well prepared raw extracts associated with equally stalk bark as well as fruits applying distilled drinking water, ethanol or even ethyl acetate. Experts next tried your extracts next to gram-negative as well as gram-positive microorganisms. Inside a survey on their conclusions inside a 2002 problem on the “South African-american Diary associated with Botany, ” they will described stalk bark as well as fruits extracts revealed substantial antibacterial pastime next to equally strains associated with microorganisms. Most of these conclusions possess smooth the best way with regard to the use of kigelia extract with skin-cleansing real estate agents along with items designed to fight microbe skin color transmissions.

Kigelia Africana Creme Encourages Skin Healing

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Kigelia Africana Creme Facilitates Firm Skin

A new five-member American indian group associated with experts started an assessment your medical materials protecting scientific studies into kigelia’s therapeutic as well as cosmeceutical components. Of their survey, posted inside a the year just gone problem associated with “Natural Item Radiance” — identified with 2011 because “Indian Diary associated with Healthy Merchandise as well as Resources” — they will reported by scientific studies that identified kigelia’s active ingredients contain steroidal saponins along with the flavonoids luteolin as well as quercetin. Most of these phytochemicals support fortify as well as stabilize your collagen materials that service your skin layer, therefore creating a firming influence. Many scientific studies identified the extract had been specifically efficient with firming your skin layer in and around your breasts.

Kigelia Africana Creme Combats Cancer

Experts with North Eire performed a great with vitro analyze to measure the capability of varied compounds from your kigelia pinnata fruits to halt your distributed associated with human most cancers cells. The main traction for your analyze had been the standard use of your fruits by means of people healers to help remedy skin color cancers along with skin color problems. Scientists isolated numerous compounds from your kigelia fruits as well as tried these people next to most cancers cells in the science lab. These people identified substantial anti-cancer components via various kigelia compounds, including the isocoumarins demethylkigelin as well as kigelin; oleic as well as heneicosanoic fatty acids; ferulic acidity; along with the furonaphthoquinone 2-(1-hydroxyethyl)naphtho[2, 3-b]furan-4, 9-dione. Of their conclusions, posted inside a 2010 problem associated with “Planta Medica, ” research workers noted the furonaphthoquinone had been in addition efficient with vitro next to 2 strains associated with breasts cancers cells.

Various other Epidermis Rewards

Inside it’s report on your materials protecting kigelia’s cosmeceutical apps, your experts on the the year just gone “Natural Item Radiance” write-up described kigelia was already trusted being an active component in a number of beauty supplements. These items can grant skin color a smoother look by means of cutting down good wrinkles as well as wrinkle detail. In addition they are usually shown to market skin color elasticity, by natural means lighten skin color, minimize spots as well as increase circulation towards skin color.

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